id: Pfam:PF08864
pfam_id: PF08864
name: ReoY-like, N-terminal domain
short_name: ReoY_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08864
counters:
  proteins: 1238
  matches: 1238
  proteomes: 1139
  taxa: 1562
  structures: 1
  alphafold_models: 807
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014963
description: This entry represents the N-terminal domain of Peptidoglycan synthesis regulatory protein
  ReoY ([swissprot:Q8Y5Y2]) which is involved in the PASTA kinase-mediated signalling pathway regulating
  peptidoglycan synthesis to maintain cell wall integrity [[cite:PUB00104135]]. It modulates peptidoglycan
  (PG) synthesis pathway committed-step enzyme MurA [[cite:PUB00104135]]. ReoY positively modulates ClpCP-dependent
  proteolysis of MurA, thereby regulating PG synthesis and inhibiting intrinsic cephalosporin resistance
  [[cite:PUB00104135]].