id: Pfam:PF08876
pfam_id: PF08876
name: Domain of unknown function (DUF1836)
short_name: DUF1836
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08876
counters:
  proteins: 2153
  matches: 2156
  proteomes: 1785
  taxa: 2610
  structures: 0
  alphafold_models: 1398
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014975
description: This protein family appears to be primarily involved in transcriptional regulation and cellular
  processes. Members of this family, such as the one represented by [swissprot:Q8E4L3] (gene gbs1388),
  exhibit high levels of transcriptional activity and may be regulated by factors like the rex gene, indicating
  a role in significant cellular processes [[cite:PUB00156067]]. Another member, [swissprot:A6M310], gene
  name cbei_4884), is implicated in strain degeneration and regulatory functions linked to sporulation
  and solvent formation in Clostridium beijerinckii, suggesting conservation among clostridial species
  [[cite:PUB00156068]]. The sgo_1308 gene encodes a protein [swissprot:A8AXS9] containing the DUF1836
  domain which belongs to the helix-turn-helix (HTH) clan, hinting at its role in transcriptional regulation,
  specifically influencing bacterial hemolysin III [[cite:PUB00156066]].