id: Pfam:PF08900
pfam_id: PF08900
name: Transcriptional regulator AcaB
short_name: AcaB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08900
counters:
  proteins: 720
  matches: 720
  proteomes: 596
  taxa: 1057
  structures: 0
  alphafold_models: 414
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014996
description: This family of proteins is found in the IncC family of broad-host-range plasmids which enables
  the spread of antibiotic resistance genes among human enteric pathogens. Recently, AcaB member has been
  characterised as a transcriptional regulator that plays a crucial role in the regulation of IncC conjugation.
  It is a DNA binding protein which binds upstream of the acaDB promoter to increase its transcription
  and, in turn, acaDB activates the transcription of IncC conjugation genes. Structurally, AcaB consists
  of two helical hairpins in tandem which assemble into an anti-parallel four-helix bundle to form a two-stranded
  antiparallel beta-sheet positioned parallel to the helices. This is structurally similar to bacterial
  transcription factors from the ribbon-helix-helix (RHH) superfamily [[cite:PUB00098625]].