id: Pfam:PF08935
pfam_id: PF08935
name: Viral protein VP4 subunit
short_name: VP4_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08935
counters:
  proteins: 93
  matches: 93
  proteomes: 36
  taxa: 86
  structures: 10
  alphafold_models: 35
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015031
description: This domain is predominantly found in viral proteins from the family Picornaviridae. It is
  VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies
  each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice [[cite:PUB00109098]].
  VP4 is on the inside and differs from the others in being small, myristoylated and having an extended
  structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest,
  along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process
  for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini
  of VP1 [[cite:PUB00109099]].