id: Pfam:PF08937
pfam_id: PF08937
name: Thoeris protein ThsB, TIR-like domain
short_name: ThsB_TIR
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08937
counters:
  proteins: 2293
  matches: 2293
  proteomes: 1821
  taxa: 3640
  structures: 8
  alphafold_models: 1413
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015032
description: Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB,
  via NAD+ degradation [[cite:PUB00097806],[cite:PUB00101118],[cite:PUB00101117]]. ThsA has robust NAD+
  cleavage activity and and a two-domain architecture containing a N-terminal NAD-binding domain (denoted
  as sirtuin-like or Macro) and C-terminal SLOG-like domain. In some instances, such as in B. amyloliquefaciens
  ThsA has an N-terminal transmembrane domain [[cite:PUB00097806]]. ThsB (also referred to as TIR1 and
  TIR2) is structurally similar to TIR domain proteins but without enzymatic activity. This is the TIR-like
  domain of ThsB proteins, which adopts a Rossmann-like fold. ThsB is responsible for recognizing phage
  infection [[cite:PUB00101118]].