id: Pfam:PF08961
pfam_id: PF08961
name: Nuclear receptor-binding factor 2, autophagy regulator
short_name: NRBF2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08961
counters:
  proteins: 1024
  matches: 1024
  proteomes: 729
  taxa: 2224
  structures: 1
  alphafold_models: 919
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015056
description: NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived
  proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein
  - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3
  kinase) activity and autophagy induction [[cite:PUB00078728]].