id: Pfam:PF08962
pfam_id: PF08962
name: Rv2632c-like
short_name: Rv2632c-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08962
counters:
  proteins: 2482
  matches: 2482
  proteomes: 1537
  taxa: 1847
  structures: 3
  alphafold_models: 1265
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015057
description: This entry includes a set of Actinobacterial proteins, including Rv2632c from Mycobacterium
  tuberculosis that is strongly implicated in the onset of non-replicating persistence, and thereby latent
  tuberculosis. Rv2632c contains a dsRBD-like (2 layers alpha/beta) fold (PDBe:2fgg). It shares remarkable
  similarity with bacterial hibernation factors, despite very low sequence similarity. Based on this structure
  it was predicted that Rv1738, highly up-regulated in conditions that mimic the onset of persistence,
  helps trigger dormancy by association with the bacterial ribosome [[cite:PUB00097447]].