id: Pfam:PF08975
pfam_id: PF08975
name: Domain of unknown function (DUF1868)
short_name: 2H-phosphodiest
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08975
counters:
  proteins: 762
  matches: 763
  proteomes: 685
  taxa: 1467
  structures: 1
  alphafold_models: 532
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015069
description: This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352
  from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus
  and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large
  eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into
  a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin
  and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or
  parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes
  of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for
  these proteins in regulating the viral tRNA metabolism. Each member of this family contains an internal
  duplication, each of which contains an HXTX motif that defines the family.