id: Pfam:PF08988
pfam_id: PF08988
name: Type III secretion system, cytoplasmic E component of needle
short_name: T3SS_needle_E
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08988
counters:
  proteins: 270
  matches: 270
  proteomes: 241
  taxa: 460
  structures: 7
  alphafold_models: 178
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR012671
description: T3SS_needle_E is a family of proteins from the operon that builds and controls the needle
  of the injection system of type III secretion. The YscE protein, produced by the pathogen Yersinia,
  assumes a secondary structure composed of two anti-parallel alpha-helices separated by a flexible loop
  [[cite:PUB00049490]]. The family is cytoplasmic and may help to stabilise and prevent early polymerisation
  of the needle-protein F [[cite:PUB00048615],[cite:PUB00109133]].