id: Pfam:PF08991
pfam_id: PF08991
name: Cx9C motif-containing protein 4
short_name: CMC4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF08991
counters:
  proteins: 1928
  matches: 1928
  proteomes: 1755
  taxa: 5263
  structures: 3
  alphafold_models: 1686
  domain_architectures: 30
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027179
description: Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices
  that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows
  a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix
  hydrophobic contacts impart stability to this scaffold [[cite:PUB00024565]]. The precise function of
  this eukaryotic domain is, as yet, unknown [[cite:PUB00013217]]. Cx9C motif-containing protein 4 (CMC4,
  also known as Mature T-cell proliferation 1 neighbor protein) is found in mitochondria. CMC4 is the
  first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype [[cite:PUB00075489]].