id: Pfam:PF09005
pfam_id: PF09005
name: Far upstream element-binding protein, C-terminal
short_name: FUBP_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09005
counters:
  proteins: 4547
  matches: 7000
  proteomes: 1177
  taxa: 3896
  structures: 2
  alphafold_models: 3925
  domain_architectures: 66
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015096
description: This entry represents the transactivation domain of Far upstream element-binding protein
  1/2 (FUBP1/2) which is found at the C-terminal. FUBP1 regulates MYC expression by binding to a single-stranded
  far-upstream element (FUSE) upstream of the MYC promoter. FUBP2, also known as KSRP (K homology-type
  splicing regulatory protein), is a single-strand-RNA binding protein that integrate different levels
  of gene expression and is required for proper immune response, lipid metabolism, cell fate decisions,
  and tissue regeneration [[cite:PUB00084324]]. This domain contains the tyrosine residues required for
  transactivation and adopts an alpha-helical configuration [[cite:PUB00159898]].