id: Pfam:PF09153
pfam_id: PF09153
name: Methylated DNA-protein cysteine methyltransferase, N-terminal
short_name: MGMT_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09153
counters:
  proteins: 36
  matches: 36
  proteomes: 35
  taxa: 61
  structures: 1
  alphafold_models: 35
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015236
description: This domain is found in the archaeal protein O6-alkylguanine-DNA alkyltransferase (also known
  as Methylated DNA-protein cysteine methyltransferase MGMT), adopt a secondary structure consisting of
  a three stranded antiparallel beta-sheet and three alpha helices. This entry represents the N-terminal
  ribonuclease H-like domain, associated with 6-O-methylguanine DNA methyltransferase activity. The exact
  function has not, as yet, been defined, though it has been postulated that they confer thermostability
  to the archaeal protein [[cite:PUB00027330]].