id: Pfam:PF09324
pfam_id: PF09324
name: Mon2/Sec7/BIG1-like, HDS
short_name: Sec7-like_HDS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09324
counters:
  proteins: 12400
  matches: 12422
  proteomes: 3349
  taxa: 8869
  structures: 1
  alphafold_models: 1000
  domain_architectures: 230
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015403
description: This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal
  of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7,
  protein Mon2 and BIG1-like proteins [[cite:PUB00101185],[cite:PUB00101184]]. Sec7 is involved in the
  secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of
  the VTC intermediate compartments for Golgi compartment biogenesis [[cite:PUB00076747]]. Sec7 has four
  HDS1-4 domains, which act to integrate the signals from several small GTPases, including Arf1 itself,
  to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [[cite:PUB00101184]].