id: Pfam:PF09327
pfam_id: PF09327
name: Bacteriophage tail tip fiber protein
short_name: Phage_Tail_Tip
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09327
counters:
  proteins: 1499
  matches: 1531
  proteomes: 1211
  taxa: 2365
  structures: 14
  alphafold_models: 418
  domain_architectures: 53
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR015406
description: The Tail Tip Fiber Protein family includes proteins involved in the attachment and penetration
  of bacteriophages into host cells. Members of this family are responsible for recognizing and irreversibly
  binding to specific host receptors, which triggers structural changes in the viral tail necessary for
  the injection of viral DNA into the host. This process is critical for the successful infection and
  propagation of the virus. The family includes proteins that initiate distal tail tip assembly during
  phage tail assembly and play a key role in the virus entry by mediating the attachment to the host receptor
  and inducing DNA ejection through the receptor's pore. This entry represents the beta prism domain which
  is formed from a homotrimeric complex of members of this family.