id: Pfam:PF09407
pfam_id: PF09407
name: AbiEi antitoxin C-terminal domain
short_name: AbiEi_1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09407
counters:
  proteins: 3687
  matches: 3687
  proteomes: 1878
  taxa: 2717
  structures: 1
  alphafold_models: 2379
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018547
description: AbiEi_1 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial
  abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi
  system is activated upon infection with phage to abort the cell thus preventing the spread of phage
  through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded
  lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the
  plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread
  in bacteria and archaea. The cognate antitoxin is [pfam:PF13338] [[cite:PUB00075538]].