id: Pfam:PF09415
pfam_id: PF09415
name: CENP-S associating Centromere protein X
short_name: CENP-X
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09415
counters:
  proteins: 2465
  matches: 2529
  proteomes: 2090
  taxa: 5655
  structures: 24
  alphafold_models: 2089
  domain_architectures: 30
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018552
description: The centromere, essential for faithful chromosome segregation during mitosis, has a network
  of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in
  vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses
  based on functional and biochemical analyses. These provide a platform for the formation of a functional
  kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex
  but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions
  downstream of other components of the CCAN. This complex may directly allow efficient and stable formation
  of the outer kinetochore on the CCAN platform.