id: Pfam:PF09430
pfam_id: PF09430
name: ER membrane protein complex subunit 7, beta-sandwich domain
short_name: EMC7_beta-sandw
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09430
counters:
  proteins: 3924
  matches: 3930
  proteomes: 3079
  taxa: 8340
  structures: 9
  alphafold_models: 3381
  domain_architectures: 103
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019008
description: This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [[cite:PUB00096682],[cite:PUB00096681]],
  which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane
  protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized
  membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored
  proteins and co-translational insertion of multipass membrane proteins [[cite:PUB00096679],[cite:PUB00096678]].
  This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain
  is also found in nodal modulators, which have been identified as part of a protein complex that participates
  in the nodal signalling pathway during vertebrate development [[cite:PUB00054165]].