id: Pfam:PF09687
pfam_id: PF09687
name: Plasmodium RESA N-terminal
short_name: PRESAN
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09687
counters:
  proteins: 854
  matches: 867
  proteomes: 25
  taxa: 93
  structures: 2
  alphafold_models: 751
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019111
description: The short, four-helical domain first identified in the Plasmodium export proteins PHISTa
  and PHISTc [[cite:PUB00053439]] has been extended to become this six-helical PRESAN domain identified
  in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association
  with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete
  copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera,
  suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium
  undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived
  from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold
  with six conserved helical segments. There is some evidence it might localise to membranes [[cite:PUB00055558]].