id: Pfam:PF09722
pfam_id: PF09722
name: Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain
short_name: Xre_MbcA_ParS_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09722
counters:
  proteins: 7332
  matches: 7333
  proteomes: 4456
  taxa: 6594
  structures: 8
  alphafold_models: 4658
  domain_architectures: 40
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024467
description: This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin
  (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium
  sp. [[cite:PUB00098292],[cite:PUB00098291],[cite:PUB00093678],[cite:PUB00098290]]. This domain interacts
  with the toxin component and sterically blocks its active site, neutralising its effect [[cite:PUB00098291],[cite:PUB00093678]].
  These antitoxins also have a HTH domain at the N-terminal.