id: Pfam:PF09736
pfam_id: PF09736
name: Pre-mRNA-splicing factor of RES complex
short_name: Bud13
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09736
counters:
  proteins: 3825
  matches: 3843
  proteomes: 3179
  taxa: 8415
  structures: 19
  alphafold_models: 3224
  domain_architectures: 59
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018609
description: This entry is characterised by proteins with alternating conserved and low-complexity regions.
  Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex.
  called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential
  for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore,
  inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically
  conserved C-terminal region of unknown function [[cite:PUB00042559]].