id: Pfam:PF09738
pfam_id: PF09738
name: LRRFIP family
short_name: LRRFIP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09738
counters:
  proteins: 7493
  matches: 12575
  proteomes: 1252
  taxa: 4062
  structures: 1
  alphafold_models: 5721
  domain_architectures: 40
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019139
description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus
  sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [[cite:PUB00078055]].
  LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3,
  upstream of CTNNB1/beta-catenin [[cite:PUB00078057]].