id: Pfam:PF09745
pfam_id: PF09745
name: Nuclear speckle splicing regulatory protein 1, N-terminal
short_name: NSRP1_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09745
counters:
  proteins: 3772
  matches: 3787
  proteomes: 3150
  taxa: 8427
  structures: 0
  alphafold_models: 3230
  domain_architectures: 73
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018612
description: This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1,
  also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains
  a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization.
  NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [[cite:PUB00093376],[cite:PUB00093375]].