id: Pfam:PF09836
pfam_id: PF09836
name: HvfC C-terminal domain
short_name: HvfC_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09836
counters:
  proteins: 4947
  matches: 4947
  proteomes: 3810
  taxa: 5510
  structures: 1
  alphafold_models: 3034
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018640
description: This entry describes the N-terminal domain in HvfC ([swissprot:Q4QL34]), NGO_1945 ([swissprot:Q5F5I0],
  [pdbe:3dee]), BufC1 and various other proteins partnered with MNIO family peptide modification enzymes.
  HvfC, as described in Haemophilus influenzae, is a partner protein to the multinuclear nonheme iron-dependent
  oxidase (MNIO) enzyme HvfB [swissprot:Q4QL34], and participates in post-translational modification that
  converts the precursor protein HvfA (Haemophilus virulence factor A) into a copper-binding metallophore
  and a contributor to the cell's ability to invade host cells and survive as an intracellular pathogen
  [[cite:PUB00161768],[cite:PUB00161749],[cite:PUB00161769]]. The related protein NGO_1945 occurs in a
  similar genomic context and was previously suggested to be a DNA-binding protein [[cite:PUB00057687]].
  It comprises residues 31 to 117 as a helical bundle with 4 main helices [[cite:PUB00057687]]. The C-terminal
  is represented by [[pfam:PF22106]].