id: Pfam:PF09848
pfam_id: PF09848
name: Schlafen group 3, DNA/RNA helicase domain
short_name: SLFN-g3_helicase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09848
counters:
  proteins: 4291
  matches: 4302
  proteomes: 3492
  taxa: 6469
  structures: 8
  alphafold_models: 2775
  domain_architectures: 46
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018647
description: This domain is found in at the C terminus of group 3 Schlafen proteins from mammals, and
  represents the DNA/RNA helicase domain [[cite:PUB00070629]]. Schlafen proteins are involved in the control
  of cell proliferation, induction of immune responses, and in the regulation of viral replication [[cite:PUB00070625],[cite:PUB00070629],[cite:PUB00098266]].
  These proteins inhibit DNA replication and promote cell death in response to DNA damage. They play a
  role in genome surveillance to kill cells with defective replication [[cite:PUB00098266]]. This domain
  is also found in various uncharacterised prokaryotic proteins fused to a DNA helicase, GIY-YIG or PD-(D/E)XK
  catalytic domain or HsdR-N(terminal) domain, which are similar to AAA DNA helicase, Type III restriction
  enzyme ATPase, RecD and RuvB helicase [[cite:PUB00098266]].