id: Pfam:PF09850
pfam_id: PF09850
name: Type VI secretion system protein DotU
short_name: DotU
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09850
counters:
  proteins: 5087
  matches: 5093
  proteomes: 3221
  taxa: 4650
  structures: 6
  alphafold_models: 3075
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR017732
description: DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining
  complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to
  the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which
  then tethers the peptidoglycan layer to the outer membrane [[cite:PUB00075434]].