id: Pfam:PF09856
pfam_id: PF09856
name: Short-chain fatty acyl coenzyme A regulator, C-terminal
short_name: ScfRs
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09856
counters:
  proteins: 5479
  matches: 5482
  proteomes: 3503
  taxa: 4680
  structures: 4
  alphafold_models: 3623
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018653
description: This entry includes short-chain fatty acid regulators such as RAMB (regulator of acetate
  metabolism B), PCCR (Propionyl-CoA carboxylase regulator), PrpR (Propionate regulator). RamB is a negative
  transcriptional regulator of genes involved in acetate metabolism of C. glutamicum. It is responsible
  for expression control of the AK, PTA, ICL, and MS genes and, thus, for the proper adaptation to acetate
  as carbon and energy source. Nucleotide sequence analysis indicate the RamB protein consists of 469
  aa with a putative HTH motif at the N terminus [[cite:PUB00074928]]. PCCR prevents the accumulation
  of propionyl-CoA by controlling expression of the gene encoding propionyl-CoA carboxylase, which is
  responsible for propionyl-CoA consumption by Rhodobacter sphaeroides. Many other Proteobacteria and
  Actinomycetales contain one or several PccR homologs that group into distinct clades on the basis of
  the pathway of acyl-CoA metabolism that they control [[cite:PUB00076849]]. PrpR is a transcriptional
  activator controlling prpDBC2 operon which encodes enzymes 2-methylcitrate dehydratase (PrpD2), 2-methylisocitrate
  lyase (PrpB2) and 2-methylcitrate synthase (PrpC2). They are essential for growth with propionate as
  carbon source. The regulatory protein belongs to the HTH_XRE regulator family. It has a length of 441
  amino acids and an N-terminal lamda repressor-like DNA-binding domain [[cite:PUB00106935]]. This is
  the C-terminal domain, which is likely an iron sensor domain that adopts a GAF-like fold [[cite:PUB00100702]].