id: Pfam:PF09864
pfam_id: PF09864
name: Membrane-bound lysozyme-inhibitor of c-type lysozyme
short_name: MliC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09864
counters:
  proteins: 4043
  matches: 4095
  proteomes: 3595
  taxa: 5116
  structures: 6
  alphafold_models: 2513
  domain_architectures: 37
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018660
description: Lysozymes are ancient and important components of the innate immune system of animals that
  hydrolyse peptidoglycan, the major bacterial cell wall polymer. Various mechanisms have evolved by which
  bacteria can evade this bactericidal enzyme, one being the production of lysozyme inhibitors. MliC (membrane
  bound lysozyme inhibitor of c-type lysozyme) of E. coli and Pseudomonas aeruginosa, possess lysozyme
  inhibitory activity and confer increased lysozyme tolerance upon expression in E. coli [[cite:PUB00054072]].
  Structural analyses show that the invariant loop of MliC plays a crucial role in the inhibition of the
  lysozyme by its insertion into the active site cleft of the lysozyme, where the loop forms hydrogen
  and ionic bonds with the catalytic residues [[cite:PUB00051886]].