id: Pfam:PF09867
pfam_id: PF09867
name: TagF N-terminal domain, Type VI secretion system-associated
short_name: TagF_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09867
counters:
  proteins: 2309
  matches: 2312
  proteomes: 1976
  taxa: 2835
  structures: 3
  alphafold_models: 1373
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR017748
description: This is the N-terminal domain of the T6S-associated protein, TagF. A post-translational repressor
  of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS)
  found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria
  and is implicated in diverse processes including host-cell interactions, biofilm formation and gene
  regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions.
  TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1,
  PpkA, or other Tag proteins. Additionally TagF is found to associate as a homodimer with nearly identical
  monomers composed of alpha and beta elements assembled as a three-layer sandwich (alpha-beta-alpha)
  [[cite:PUB00086563]].