id: Pfam:PF09873
pfam_id: PF09873
name: SepCysE-like
short_name: SepCysE
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09873
counters:
  proteins: 38
  matches: 38
  proteomes: 38
  taxa: 82
  structures: 4
  alphafold_models: 35
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR016736
description: This family includes MJ1481 from Methanocaldococcus jannaschii and similar archaeal proteins.
  MJ1481 has been reported to be SepCysE, a translation factor, essential for the methanococcal Cys biosynthesis.
  SepCysE forms a bridge between Sep-tRNA:Cys -tRNA synthase (SepCysS) and O-phosphoseryl-tRNA synthetase
  (SepRS), forming the transsulfursome complex, enabling substrate channelling of Sep-tRNACys [[cite:PUB00093677],[cite:PUB00093676]].