id: Pfam:PF09907
pfam_id: PF09907
name: HigB_toxin, RelE-like toxic component of a toxin-antitoxin system
short_name: HigB_toxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09907
counters:
  proteins: 3199
  matches: 3200
  proteomes: 2308
  taxa: 4015
  structures: 4
  alphafold_models: 2061
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018669
description: HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases.
  HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs
  to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress
  factors.