id: Pfam:PF09949
pfam_id: PF09949
name: Phosphatidate phosphatase APP1, catalytic domain
short_name: APP1_cat
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09949
counters:
  proteins: 7412
  matches: 7431
  proteomes: 4992
  taxa: 7879
  structures: 0
  alphafold_models: 5212
  domain_architectures: 76
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019236
description: This entry represents a conserved region found in Phosphatidate phosphatase APP1 from yeast,
  which contains the catalytic motif DXDX(T/V) [[cite:PUB00071676],[cite:PUB00098278]], present in other
  Mg+2-dependent phosphatases. This domain has a weak sequence similarity to the haloacid dehalogenase-like
  domain [[cite:PUB00071676]]. APP1 catalyses the dephosphorylation of phosphatidate to yield diacylglycerol
  and may play a role in vesicular trafficking through its phosphatidate phosphatase activity at cortical
  actin patches [[cite:PUB00071676],[cite:PUB00098278]].