id: Pfam:PF09992
pfam_id: PF09992
name: Phosphodiester glycosidase
short_name: NAGPA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09992
counters:
  proteins: 11558
  matches: 11569
  proteomes: 7460
  taxa: 12626
  structures: 9
  alphafold_models: 7114
  domain_architectures: 247
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018711
description: This is a family conserved from bacteria to humans. The structure of a member from Bacteroides
  has been crystallised and modelled onto the luminal region of the human member of the family, the transmembrane
  glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation
  of potentially functional residues, implying that in the bacterial members this family acts in some
  way as a phosphodiester glycosidase [[cite:PUB00078675]]. The human protein is also present, so the
  eukaryotic members are likely to be catalysing the second step in the formation of the mannose 6-phosphate
  targeting signal on lysosomal enzyme oligosaccharides [[cite:PUB00108993]].