id: Pfam:PF09994
pfam_id: PF09994
name: T6SS, Phospholipase effector Tle1-like, catalytic domain
short_name: T6SS_Tle1-like_cat
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09994
counters:
  proteins: 12473
  matches: 13510
  proteomes: 4775
  taxa: 7945
  structures: 4
  alphafold_models: 9172
  domain_architectures: 286
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018712
description: This domain is found in the type VI secretion system (T6SS) protein Phospholipase effector
  Tle1 from Pseudomonas aeruginosa ([swissprot:Q9HYV3]), which hydrolyse membrane phospholipids. Tle1
  is organised into two distinct parts, the phospholipase catalytic module (this entry) and the putative
  membrane-anchoring module ([pfam:PF22137]). This domain adopts a compact conformation with a classical
  mixed alpha/beta-hydrolase fold that shows of seven central parallel beta-sheets and 13 alpha-helices
  [[cite:PUB00154252]].