id: Pfam:PF10017
pfam_id: PF10017
name: Histidine-specific methyltransferase, SAM-dependent
short_name: Methyltransf_33
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10017
counters:
  proteins: 9308
  matches: 9704
  proteomes: 7637
  taxa: 11798
  structures: 17
  alphafold_models: 6174
  domain_architectures: 79
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019257
description: The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic
  gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino
  moiety of histidine, in the first stage of the production of this histidine betaine derivative that
  carries a thiol group attached to the C2 atom of an imidazole ring [[cite:PUB00060032]].