id: Pfam:PF10034
pfam_id: PF10034
name: Q-cell neuroblast polarisation
short_name: Dpy19
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10034
counters:
  proteins: 4728
  matches: 5527
  proteomes: 1248
  taxa: 3917
  structures: 4
  alphafold_models: 4145
  domain_architectures: 53
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018732
description: 'Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to
  orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born
  in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating
  towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express
  mab-5 correctly in the Q cell descendants [[cite:PUB00044879]]. The Dpy-19 protein derives from the
  C. elegans DUMPY mutant, [swissprot:P34413].'