id: Pfam:PF10040
pfam_id: PF10040
name: CRISPR-associated endoribonuclease Cas6
short_name: CRISPR_Cas6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10040
counters:
  proteins: 1540
  matches: 1540
  proteomes: 1154
  taxa: 2835
  structures: 11
  alphafold_models: 1115
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019267
description: Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily [[cite:PUB00043288]].
  It is among the most widely distributed Cas proteins and is found in both bacteria and archaea [[cite:PUB00020781]].
  Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes [[cite:PUB00054084]].