id: Pfam:PF10048
pfam_id: PF10048
name: BufA1 family periplasmic bufferin-type metallophore
short_name: BufA1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10048
counters:
  proteins: 3198
  matches: 3200
  proteomes: 2492
  taxa: 3581
  structures: 0
  alphafold_models: 2072
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018740
description: BufA1 family periplasmic bufferin-type metallophore belongs to a family of ribosomally synthesised
  and post-translationally modified peptide (RiPP) precursors that are modified by multinuclear nonheme
  iron-dependent oxidase (MNIO) enzymes. Unusual among RiPPs, these peptides have an Sec-dependent N-terminal
  signal peptide, and are delivered to the periplasm. Members of this family act as metallophores, analogous
  to methanobactin, can be induced by stress from excess concentrations of copper or other metals, reduce
  metal toxicity by sequestration, and are termed bufferins [[cite:PUB00161747],[cite:PUB00161748],[cite:PUB00161749]].