id: Pfam:PF10058
pfam_id: PF10058
name: ER junction formation factor lunapark, zinc ribbon finger
short_name: Zn_ribbon_10
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10058
counters:
  proteins: 4482
  matches: 4485
  proteomes: 2989
  taxa: 7983
  structures: 0
  alphafold_models: 3819
  domain_architectures: 81
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019273
description: This zinc ribbon domain is found in Endoplasmic reticulum junction formation protein (LNP1)
  and other related eukaryotic proteins. LNP1 plays a role in endoplasmic reticulum (ER) network formation
  [[cite:PUB00155939]]. It binds to the reticulons and Yop1p and resides at ER tubule junctions in both
  yeast and mammalian cells [[cite:PUB00155939]]. Lnp1 dimerises in vitro via this zinc finger domain
  and this is required for proper ER structure but not for the nuclear pore complex (NPC) integrity [[cite:PUB00155940]].
  The latter role is determined by the interactions with other ER components, including Rtn1, Yop1, Pom33,
  and Per33 [[cite:PUB00155940]].