id: Pfam:PF10073
pfam_id: PF10073
name: GapR-like, DNA-binding domain
short_name: GapR_DNA-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10073
counters:
  proteins: 3528
  matches: 3530
  proteomes: 2569
  taxa: 3722
  structures: 9
  alphafold_models: 2397
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046367
description: GapR is a nucleoid-associated protein (NAP) critical for cellular function in Caulobacter
  crescentus (also known as Caulobacter vibrioides). Loss of GapR causes severe defects in growth, cell
  division, DNA replication, and chromosome segregation [[cite:PUB00100154],[cite:PUB00100155]]. This
  is a DNA-binding protein which has mainly an alpha-helical secondary structure. In the absence of DNA,
  GapR is a dimer, with each monomer folded into two extended alpha-helices, while in the presence of
  DNA, GapR forms a tetramer, with the C-terminal alpha-helix of each monomer reorganised into two shorter
  helices, which allows GapR to encircle the DNA [[cite:PUB00070793],[cite:PUB00100154],[cite:PUB00100155]].
  This is the DNA-binding domain of GapR from Caulobacter crescentus and related sequences. This domain
  is not only highly conserved in Alphaproteobacteria, it is also present in cyanobacteria, firmicutes,
  planctomycetes, actinobacteria, and even archaea and eukaryotes, possibly through horizontal gene transfer.
  This domain is also found in phages, in which it is associated to DNA-related processes [[cite:PUB00100154]].