id: Pfam:PF10074
pfam_id: PF10074
name: T6SS, Transcription factor, DNA binding domain
short_name: RovC_DNA-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10074
counters:
  proteins: 2443
  matches: 2443
  proteomes: 1012
  taxa: 1628
  structures: 2
  alphafold_models: 1599
  domain_architectures: 12
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018754
description: This domain is found in a group of proteins from proteobacteria, including the hexameric
  transcription factor from Yersinia pseudotuberculosis RovC, which is essential for the activation of
  one of the Type VI secretion systems of this organism (T6SS4). This domain folds into a distinct variant
  of the helix-turn-helix domain that shows an 'extended-turn' motif. It is responsible for DNA binding,
  participating in transcriptional activation and antiactivation to initiate or inhibit horizontal gene
  transfer [[cite:PUB00152791],[cite:PUB00152792]].