id: Pfam:PF10086
pfam_id: PF10086
name: YhfC intramembrane metalloprotease
short_name: YhfC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10086
counters:
  proteins: 814
  matches: 897
  proteomes: 763
  taxa: 1273
  structures: 0
  alphafold_models: 511
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR011397
description: This family includes proteins that are mainly from Firmicutes and Proteobacteria. Family
  members bear the consensus signature of 'EExxR' the second motif 'HxxxE' and the third motif 'H/Qxxxs'.
  The fourth motif, 'HxxxB', is shared by the PrsW proteases [pfam:PF13367] and the CPBP [pfam:PF02517],
  and APH-1 families. There are currently no experimental functional data for members of this group, however,
  they are predicted to be integral membrane proteins with several transmembrane segments and hypothesized
  metalloprotease function. YhfC intramembrane metalloprotease, CPBP family (type II CAAX Proteases and
  Bacteriocin Processing enzymes), PrsW proteases and APH-1 are distantly related. They share four predicted
  core transmembrane segments and possess similar, yet distinct sets of sequence motifs [[cite:PUB00091031]].