id: Pfam:PF10100
pfam_id: PF10100
name: Staphylopine dehydrogenase
short_name: Staph_opine_DH
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10100
counters:
  proteins: 231
  matches: 231
  proteomes: 218
  taxa: 387
  structures: 13
  alphafold_models: 128
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR016935
description: A member of this family has been identified in Staphylococcus aureus as a dehydrogenase involved
  in the synthesis of a new metallophore,named staphylopine. It is encoded as part of an operon that also
  includes an histidine racemase and an enzyme distantly related to nicotianamine synthase [[cite:PUB00081137]].
  Staphylopine is involved in metal acquisition, chelating nickel, cobalt, zinc, copper or iron, depending
  on the growing conditions. Metal acquisition is vital for bacteria growing in metal-scarce environments,
  such as inside a host in the case of pathogens.