id: Pfam:PF10104
pfam_id: PF10104
name: Di-sulfide bridge nucleocytoplasmic transport domain
short_name: Brr6_like_C_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10104
counters:
  proteins: 1884
  matches: 1891
  proteomes: 1570
  taxa: 3350
  structures: 0
  alphafold_models: 1583
  domain_architectures: 33
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR018767
description: Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi.
  It carries four highly conserved cysteine residues. It is suggested that members of the family interact
  with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport
  [[cite:PUB00044174]]. Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two
  predicted transmembrane domains, and is a dosage suppressor of Apq12, [pfam:PF12716] [[cite:PUB00055994]].