id: Pfam:PF10151
pfam_id: PF10151
name: TMEM214, C-terminal, caspase 4 activator
short_name: TMEM214
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10151
counters:
  proteins: 2721
  matches: 2917
  proteomes: 1404
  taxa: 4532
  structures: 0
  alphafold_models: 2280
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019308
description: This is the N-terminal domain of transmembrane family 214, from eukaryotes. The family is
  localised on the endoplasmic reticulum where it recruits procaspase 4 to the ER and subsequently allows
  this to be cleaved to caspase 4 so leading to apoptosis [[cite:PUB00078722]].