id: Pfam:PF10157
pfam_id: PF10157
name: BLOC-1-related complex sub-unit 6 C-terminal helix
short_name: BORCS6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10157
counters:
  proteins: 1983
  matches: 1984
  proteomes: 1541
  taxa: 4966
  structures: 1
  alphafold_models: 1674
  domain_architectures: 36
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046465
description: This is a family of conserved proteins found from nematodes to humans. Family members include
  BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or
  C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit
  complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects
  cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small
  GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of
  lysosomes toward the cell periphery [[cite:PUB00082308],[cite:PUB00074975]]. this entry represents a
  C-terminal alpha helix according to structure predictions.