id: Pfam:PF10164
pfam_id: PF10164
name: Brain protein I3
short_name: BRI3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10164
counters:
  proteins: 1725
  matches: 1731
  proteomes: 1240
  taxa: 4040
  structures: 0
  alphafold_models: 1526
  domain_architectures: 15
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019317
description: This is a highly conserved family of proteins which contains three pairs of cysteine residues
  within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes
  a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several
  members have been assigned as brain protein I3 (Bri3) [[cite:PUB00083183]]. Their function is unknown
  but they appear to play a role in TNF-induced cell death [[cite:PUB00095376]].