id: Pfam:PF10171
pfam_id: PF10171
name: Translocase of the Inner Mitochondrial membrane 29
short_name: Tim29
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10171
counters:
  proteins: 1127
  matches: 1147
  proteomes: 976
  taxa: 3362
  structures: 1
  alphafold_models: 986
  domain_architectures: 25
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019322
description: This is a family of proteins conserved from nematodes to humans. The function is not known.
  However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found
  in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and
  inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore
  translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member
  with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer
  membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex
  [[cite:PUB00083238]].