id: Pfam:PF10176
pfam_id: PF10176
name: NEDD4/Bsd2
short_name: NEDD4_Bsd2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10176
counters:
  proteins: 4457
  matches: 6814
  proteomes: 2520
  taxa: 6609
  structures: 0
  alphafold_models: 3903
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019325
description: Proteins in this entry includes NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2)
  and the yeast Bsd2 metal homeostasis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that
  bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [[cite:PUB00075325],[cite:PUB00075323]].
  Ndfip1 plays a role in regulating metal transport in human neurons [[cite:PUB00075324]].