id: Pfam:PF10179
pfam_id: PF10179
name: Neuron-derived neurotrophic factor, first Fn(III) domain
short_name: NDNF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10179
counters:
  proteins: 1828
  matches: 1834
  proteomes: 1030
  taxa: 3297
  structures: 0
  alphafold_models: 1643
  domain_architectures: 28
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR055271
description: This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF)
  which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation
  sites [[cite:PUB00092493],[cite:PUB00092492]]. NDNF is a glycosylated and disulfide-bonded secreted
  protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes
  endothelial cell survival, vessel formation and plays an important role in the process of revascularization.