id: Pfam:PF10189
pfam_id: PF10189
name: Integrator complex subunit 3 N-terminal
short_name: Ints3_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10189
counters:
  proteins: 2571
  matches: 2681
  proteomes: 1692
  taxa: 5317
  structures: 4
  alphafold_models: 2112
  domain_architectures: 65
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR019333
description: The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription,
  and in their 3'-box-dependent processing. This complex associates with the C-terminal domain of RNA
  polymerase II largest subunit and is recruited to the U1 and U2 snRNAs genes [[cite:PUB00045283]]. This
  entry represents the N-terminal domain of the Integrator complex subunit 3 (Ints3), also known as SOSS
  complex subunit A (SOSSA). It is a component of the sensor of single-stranded DNA complex (SOSS), which
  associates with single-stranded DNA, important for DNA repair and efficient homologous recombination
  [[cite:PUB00098617]]. This subunit serves as a central adaptor for SOSS complex assembly and stability,
  and facilitates the accumulation of the complex to the sites of DNA damage. This region acts as a scaffold
  for SOSSB1 and SOSSC interaction and it is not essential for ssDNA binding [[cite:PUB00098617]].